stke.sciencemag.orgScience Signaling

Skip to main content AAAS ScienceMag.org Search Search X Advanced Search Contents News Careers Journals Menu Read our COVID-19 research and news. Cover story: Microglia binge on synapses Binge drinking may cause anxiety by triggering microglia to destroy excitatory synapses sebastianosecondi/Shutterstock Coupling ligand binding to coregulator recruitment A patient-derived mutation in ERα that causes estrogen insensitivity alters coregulator recruitment Li et al. / Free Editorial: Shifting from the wrong moves to the right ones Missteps and opportunities in the tackling of the COVID-19 pandemic are discussed RyanKing999/iStock From last week: Building a better IL-10 An IL-10 variant with higher affinity for a receptor subunit remains effective at low concentrations Gorby et al. / Contents 22 September 2020 Vol 13, Issue 650 Research Articles Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior By Renato Socodato , Joana F. Henriques , Camila C. Portugal , Tiago O. Almeida , Joana Tedim-Moreira , Renata L. Alves , Teresa Canedo , Cátia Silva , Ana Magalhães , Teresa Summavielle , João B. Relvas 22 Sep 2020 Full Access Restricted Access Binge drinking may cause anxiety by triggering microglia to destroy excitatory synapses. Editor's Summary Abstract Full Text PDF Supplementary Materials A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment By Yin Li , Laurel A. Coons , René Houtman , Kathryn E. Carlson , Teresa A. Martin , Christopher G. Mayne , Diana Melchers , Tanner B. Jefferson , J. Tyler Ramsey , John A. Katzenellenbogen , Kenneth S. Korach 22 Sep 2020 Full Access Restricted Access A patient-derived mutation in ERα that causes estrogen insensitivity alters coregulator recruitment. Editor's Summary Abstract Full Text PDF Supplementary Materials Editors' Choice Zika and ubiquitin By John F. Foley 22 Sep 2020 Full Access Restricted Access Ubiquitylation of the Zika virus envelope protein drives viral entry and pathogenesis. Abstract Full Text More From Current Table of Contents First Release Archive About Mission and Scope Editorial Board Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Frequently Asked Questions Journal Help Subscribe Remote Access for Current Subscribers Editor's Blog Get the eTOC Alert Submit Free Sample Articles About The Cover Online Cover This week features a Research Article that shows how binge drinking activates brain-resident macrophages to engulf and destroy excitatory synapses. The loss of these neuronal connections promoted anxiety-like behavior in mice. [Image: sebastianosecondi/Shutterstock] Read the Latest Issue of Science 25 September 2020 Vol 369, Issue 6511 Table of Contents Feature Seeking a niche Regulation: COVID-19 Self-experimentation, ethics, and regulation of vaccines Quantum Mechanics Understanding quantum cause and effect SCI COMMUN News at a glance Microbiology Transformative tools for parasitic flatworms Working Life Full disclosure About Us Journals News from Science Leadership Team Members Work at AAAS For Advertisers Advertising Kits Awards and Prizes Custom Publishing Webinars For Authors Submit Information for Authors Editorial Policies For Librarians Manage Your Institutional Subscription Information for Librarians Request a Quote FAQs Related Sites AAAS.org EurekAlert! Science in the Classroom Science Magazine Japanese Help Access and Subscriptions Order a Single Issue Reprints and Permissions Contact Us Accessibility Stay Connected Facebook Twitter YouTube RSS Feeds © 2020 American Association for the Advancement of Science . All rights reserved. AAAS is a partner of HINARI , AGORA , OARE , CHORUS , CLOCKSS , CrossRef and COUNTER . ISSN 1937-9145. Terms of Service Privacy Policy Contact AAAS...